The Last Man on Earth (1964), starring Vincent Price
Vincent Price stars in the first, and best, adaptation of Richard Matheson”s classic horror/sci-fi novel I Am Legend. After a plague wipes out the human race, Dr. Robert Morgan (Price) struggles with loneliness. And with his sanity as the monotony of the unending days broken only by his daily hunts for vampires! One day on his solitary travels he runs across another surviving human: is she a mirage, or real?